Molecular Details
DICL_CP_0326391
- 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
Basic Molecular Information
Basic Information
DICL ID
DICL_CP_0326391
PubChem CID
Molecular Formula
C17H17N3O2 Molecular Weight
295.342 g/mol
Synonyms/Alias
[PJ34; 344458-19-1; pj-34; N~2~N~2~-DIMETHYL-N~1~-(6-OXO-56-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE; 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide; 2-(dimethylamino)-N-(6-oxo-56-dihydrophen...
InChI Key
UYJZZVDLGDDTCL-UHFFFAOYSA-N
InChI
InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-...
IUPAC Name
2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
CAS Number
344458-19-1
Structure Information
Chemical Structure Visualization
SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF
39 41 0 0 0 0 0 0 0 0999 V2000
5.6709 -0.1837 1.3680 C 0 0 0 0 0 0 0 0 0 0 0 0
4.5065 0.1276 0.5240 N 0 0 0 0 0 0 0 0 0 0 0 0
4.8310 1.258...
Experimental Data
Activity Data
Target Ion Channel
Transient receptor potential cation channel subfamily M member 2
Uniprot Accession Number
Function
Inhibitor
Species
Homo sapiens (Human)
IC50
IC50: 25 nM
EC50
N/A (Not available)
Ki
N/A (Not available)
Kd
N/A (Not available)
Inhibition
N/A (Not available)
Experimental Conditions
pH
pH 7.2
Holding Potential
−100 to 100 mV mV
Temperature
21−25 °C
Test Method
Patch-clamping
Test Species
HEK293 cell (Homo sapiens embryonic kidney 293 cell)
Binding Information
Binding Site
Not specified
Binding Site Residue
Not specified
Disease Information
Related Disease
Not specified
References
Computed Properties
Heavy Atom Count
22
Rotatable Bonds
3
logP
2.1814
Complexity
89.2584
TPSA (Ų)
65.2
H-Bond Donors
2
H-Bond Acceptors
3
Ring Count
3